ABSTRACT
Objective To study the effect of ventolin combined with pulmicort in the treatment of children with asthma and its influence on inflammatory cytokines .Methods 100 children with asthma were randomly divided into observation group(50 cases) and control group(50 cases) according to the digital table.The control group was given pulmicort treatment ,the observation group was given 0.5％ ventolin combined with pulmicort .The course of treatment was 3-5 days.The remission time,the levels of inflammatory cytokines (IL-17 and TGF ) and adverse reactions were compared between the two groups .Results After treatment,the VC,FVC and PEFC of the observation group were significantly better than those of the control group ,the differences were statistically significant (t=2.412, 9.806,3.922,all P<0.05).The remission time of clinical symptoms of the observation group was better than those of the control group(t=5.182,4.576,4.166,5.761,all P<0.05 ).There was no statistically significant difference in the side effects between the two groups (18.00％vs.16.00％,χ2 =2.153,P>0.05).The levels of IL-6 and TGF in the observation group were lower than those in the control group (t =8.234,25.075,all P <0.05). Conclusion Ventolin combined with pulmicort in the treatment of children with asthma can effectively relieve clinical symptoms,reduce the inflammatory cytokines ,improve pulmonary function ,so it is worthy of further clinical application .
ABSTRACT
Objective To investigate thecurative effect of Hanchuan Zupa granule combined with ventolin atomizing inhalation in the treatment of infantile bronchial asthma and the influence of serum myeloperoxidase(MPO),neutrophil(PMN),monocyte chemotactic protein-4(MCP-4).Methods 92 cases of infantile bronchial asthma from June 2015 to June 2016 in yiwu materal and child health care family planning senice center,according to the draw method was divided into the control group(n=46)and experimental group(n=46),the control group was treated with salbutamol inhalation,and the experimental group was based on control group treated with Hanchuan Zupa granule,the curative effect,MPO,PMN,MCP-4,inflammatory factor,the T lymphocyte subgroup,arterial blood gas index,clinical symptoms disappeared time and safety of two groups were observed.Results After treatmented,the total effective rate of experimental group was 93.48％higher than that of control group 76.08％,the difference was statistically significant(P<0.05).The MPO,PMN,MCP-4 of experimental group was lower than the control group,the difference was statistically significant(P<0.05).The inflammatory factor,T lymphocyte subgroup,arterial blood gas index in the experimental group were more significantly improved than those in the control group,the difference was statistically significant(P<0.05).The clinical symptoms disappear time of experimental group was better than that of control group,the difference was statistically significant(P<0.05).There was no significant difference in safety between the two groups.Conclusion Hanchuan Zupa granule combined withventolin atomizing inhalation of children with bronchial asthma in the exact effect,and down-regulated the expression of MPO,PMN,MCP-4,promote the recovery of children.